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Each weekend, you are linked to the best article that , during each week, I have read and found it great in the field of Cancer and Pharmacology. I try to encourage the fellow researchers and post-graduate students to read so much as they can about new therapeutics.
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Weekend Recipe for January 2016 - the first week

Antibody Drug Conjugates for Cancer Therapy

Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.

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Our article: Therapeutic miRNAs


 Pharmacological Research




Headlines





Date published: not known
Details

»Understanding the formation of spicules
»Lnc-ing fibroblasts to cardiac fibrosis
»Quantum effects in ambient conditions
»How to make a protein-based nanocontainer
»The influence of flying
»Instant tough bonding of hydrogels
»PKA-activation mechanism revised
»Optimum human input
»One person's meat is another's poison
»Broadening the immune spectrum


Date published: not known
Details

»Structure and Dynamics of the Liver Receptor Homolog 1-PGC1{alpha} Complex [Articles]
Peroxisome proliferator-activated gamma coactivator 1-α (PGC1α) regulates energy metabo ...
»Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner [Articles]
The synthetic glucocorticoids (GCs) dexamethasone, mometasone furoate, and triamcinolone acetonide ...
»Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077 [Articles]
Competitive antagonists against N-methyl-D-aspartate (NMDA) receptors have played critical roles th ...
»Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein- and Receptor-Interacting Protein Kinase 1-Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induced Apoptosis [Articles]
Pannexin-1 (Panx1) channels mediate the efflux of ATP and AMP from cancer cells in response to indu ...
»Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine [Articles]
Small noncoding microRNAs act as post-transcriptional regulators of gene expression involved in div ...
»Dexamethasone Downregulates Endothelin Receptors and Reduces Endothelin-Induced Production of Matrix Metalloproteinases in Cultured Rat Astrocytes [Articles]
In brain disorders, astrocytes change phenotype to reactive astrocytes and are involved in the indu ...
»A Glutamate-Substituted Mutant Mimics the Phosphorylated and Active Form of Guanylyl Cyclase-A [Articles]
Multisite phosphorylation is required for activation of guanylyl cyclase (GC)-A, also known as NPR- ...
»Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor [Articles]
The constitutive androstane receptor (CAR) plays an important role in xenobiotic metabolism, energy ...
»Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye [Articles]
Fluorometric imaging plate reader membrane potential dye (FMP-Red-Dye) is a proprietary tool for ba ...
»Correction to "The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes" [ERRATUM]


Date published: not known
Details

»MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory
»NetNorM: Capturing cancer-relevant information in somatic exome mutation data with gene networks for cancer stratification and prognosis
»Linking structure and activity in nonlinear spiking networks
»Low-dimensional spike rate models derived from networks of adaptive integrate-and-fire neurons: Comparison and implementation
»Comorbidities in the diseasome are more apparent than real: What Bayesian filtering reveals about the comorbidities of depression
»High-confidence assessment of functional impact of human mitochondrial non-synonymous genome variations by APOGEE
»A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and inner membrane structure from confocal images
»LASSIM—A network inference toolbox for genome-wide mechanistic modeling
»Transmembrane helical interactions in the CFTR channel pore
»Olfactory learning without the mushroom bodies: Spiking neural network models of the honeybee lateral antennal lobe tract reveal its capacities in odour memory tasks of varied complexities
»Brain network eigenmodes provide a robust and compact representation of the structural connectome in health and disease
»Good enough practices in scientific computing


Date published: not known
Details


THE FOUNDER and CEO

Parham Jabbarzadeh Kaboli, PhD

Research scientist
in molecular medicine


Expert in:

Cell and molecular Biology
Modelling and drug discovery
Cancer signaling pathways

H-index= 3 (Google Scholar)
i10-index= 3
Overall ISI impact factor= 18.15
Overall citation= 110 (Google Scholar)

Memberships:

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

European Association for Cancer Research (EACR)

American Association for Advancement of Science (AAAS)



CONTACT INFORMATION


Affiliation:
Department of Biomedical Science,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang 43400,
Selangor, Malaysia

E-Mail: parham@gromacs.net
Telegram: telegram.me/parhamacademy
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