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Each weekend, you are linked to the best article that , during each week, I have read and found it great in the field of Cancer and Pharmacology. I try to encourage the fellow researchers and post-graduate students to read so much as they can about new therapeutics.
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Weekend Recipe for January 2016 - the first week

Antibody Drug Conjugates for Cancer Therapy

Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.

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Our article: Therapeutic miRNAs


 Pharmacological Research




Headlines


»Protecting PTEN in the Nucleus [News in Brief]
A recent study shows that the transport receptor Importin-11 relocates PTEN, a tumor suppressor, to ...
»New Guideline on Managing Colorectal Cancer [News in Brief]
A multidisciplinary panel of experts has issued guidelines that consolidate current evidence on tes ...
»Epigenomic Changes Prime PDAC Metastasis [News in Brief]
Widespread chromatin modifications and DNA methylation could be responsible for inducing the spread ...
»IDH-Mutant Tumors Vulnerable to PARP Inhibition [News in Brief]
Several cancers, including glioma and acute myeloid leukemia, carry mutations in IDH1 or IDH2. Rese ...
»Tracing the Path of CAR T Cells [News in Brief]
Adding a radioactive tag to CAR T cells has allowed these engineered cells to be monitored as they ...
»Ceritinib Bests Chemo for Untreated ALK+ NSCLC [News in Brief]
Patients with ALK-positive non–small cell lung cancer may soon have a new first-line treatmen ...
»Nivolumab Gets FDA Nod for Bladder Cancer [News in Brief]
The FDA has granted accelerated approval to nivolumab for patients with locally advanced or metasta ...
»Targeting the EED-H3K27me3 Interaction Allosterically Inhibits PRC2 [Epigenetics]
EED226 and A-395 bind to the H3K27me3 binding pocket of EED to allosterically inhibit PRC2.
»An Essential Gene Dataset Defines Functional Gene Networks [Genomics]
Gene essentiality pattern analysis can identify gene interactions and synthetic lethal interactions ...
»A Population of Innate Lymphoid Cells Impairs TIL Expansion in HGSC [Immunology]
Regulatory CD56+CD3– innate lymphoid cells (ILC) suppress tumor-infiltrating lymphocyte (TIL) ...


Date published: not known
Details

»Aspiring to do better than one's parents
»Pattern formation in the brain
»Getting phosphorus into healthy shape
»Taking a look at fungal bioluminescence
»Imaging an atomic soliton train
»Zinc can compete with lithium
»Ancient genomics of horse domestication
»Sensitive and specific CRISPR diagnostics
»Thinking local about building
»Single-cell diversity in the brain


Date published: not known
Details

»Correction to "Differential Contribution of Subunit Interfaces to a9a10 Nicotinic Acetylcholine Receptor Function" [ERRATUM]
»Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells [Articles]
Structurally related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate [bar ...
»p38{beta} Mitogen-Activated Protein Kinase Signaling Mediates Exenatide-Stimulated Microglial {beta}-Endorphin Expression [Articles]
Recent discoveries established that activation of glucagon-like peptide-1 receptors (GLP-1Rs) media ...
»SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance [Articles]
CD4+ T helper cells, especially T helper 17 (TH17) cells, combined with immune regulatory network d ...
»Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity [Articles]
We have reported that phosphorylation of the glucocorticoid receptor (GR) at Ser226 reduces GR nucl ...
»AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome [Articles]
Trypanosoma brucei causes human African trypanosomiasis (HAT). The pyrrolopyrimidine AEE788 (a hit ...
»Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1) [Articles]
Tumor necrosis factor α (TNFα) plays a vital role in cancer progression as it is associ ...
»The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes [Articles]
Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is e ...
»Purinergic Receptor Transactivation by the {beta}2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells [Articles]
The β2 adrenergic receptor (β2AR) increases intracellular Ca2+ in a variety of cell types ...
»Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia [Minireview]
Hyperbilirubinemia, caused by the accumulation of unconjugated bilirubin, is one of the most common ...


Date published: not known
Details

»Correction: Spatial separation of two different pathways accounting for the generation of calcium signals in astrocytes
»When do correlations increase with firing rates in recurrent networks?
»Variable habitat conditions drive species covariation in the human microbiota
»Personalized glucose forecasting for type 2 diabetes using data assimilation
»ESPRIT-Forest: Parallel clustering of massive amplicon sequence data in subquadratic time
»An aggregation-removal model for the formation and size determination of post-synaptic scaffold domains
»Representational models: A common framework for understanding encoding, pattern-component, and representational-similarity analysis
»Predicting explorative motor learning using decision-making and motor noise
»Intrinsically-generated fluctuating activity in excitatory-inhibitory networks
»Exhaustive search of linear information encoding protein-peptide recognition
»A dynamic genetic-hormonal regulatory network model explains multiple cellular behaviors of the root apical meristem of Arabidopsis thalian
»Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples


Date published: not known
Details


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PARHAM'S CURRENT POSITION

Parham Jabbarzadeh Kaboli

Lecturer and Researcher
in Molecular Pharmacology

Expert in:

Cell and molecular Biology
Modelling and drug discovery
Cancer signaling pathways

H-index= 3 (Google Scholar)
i10-index= 3
Overall impact factor= 7.55
Overall citation= 102 (Google Scholar)

Memberships:

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association of Cancer Research (AACR)

American Association for Advancement of Science (AAAS)

CONTACT INFORMATION


Affiliation:
Department of Biomedical Science,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang 43400,
Selangor, Malaysia

E-Mail: parham@gromacs.net
Telegram: telegram.me/parhamacademy
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