Parham Academy LLC
Global learning systems in Science and Medicine


Our news & hot issues


ISI Impact factor= 5.49 (Q1)



Each weekend, you are linked to the best article that , during each week, I have read and found it great in the field of Cancer and Pharmacology. I try to encourage the fellow researchers and post-graduate students to read so much as they can about new therapeutics.
-------------------------------------------

Weekend Recipe for January 2016 - the first week

Antibody Drug Conjugates for Cancer Therapy

Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.

Download this recipe

To download other weekend recipes click here.




Author watson Home 13:34:12 | | | printer friendly | | create pdf of this news item


Our article: Therapeutic miRNAs


 Pharmacological Research




Headlines





Date published: not known
Details

»When you don't want things to stick
»The circuits of itching and scratching
»Sequencing each cell of the nematode
»Unusual star may be supernova debris
»Identification of a new injection system
»A new therapeutic target in view?
»Modeling a pregnancy disorder
»Treating a tumor to metastasize
»Sharing data, protecting privacy
»Collaborative governance


Date published: not known
Details

»A Chinese Perspective on Receptors and Receptor Regulation [Commentary-Molecular Pharmacology in China]
A receptor is a protein molecule that receives chemical signals from outside a cell, which enables ...
»Progress in Pharmacological Sciences in China [Minireview-Molecular Pharmacology in China]
Pharmacology is the science that investigates the interactions between organisms and drugs and thei ...
»The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases [Minireview-Molecular Pharmacology in China]
Temperature-sensitive transient receptor potential (TRP) channels such as TRPA1 and TRPV1 have been ...
»Phosphorylation of G Protein-Coupled Receptors: From the Barcode Hypothesis to the Flute Model [Minireview-Molecular Pharmacology in China]
Seven transmembrane G protein-coupled receptors (GPCRs) are often phosphorylated at the C terminus ...
»MG53: Biological Function and Potential as a Therapeutic Target [Minireview-Molecular Pharmacology in China]
MG53 (also known as tripartite motif, TRIM72) is a cardiac and skeletal muscle-specific TRIM-family ...
»Tumor Microenvironment Targeting and Responsive Peptide-Based Nanoformulations for Improved Tumor Therapy [Minireview-Molecular Pharmacology in China]
The tumor microenvironment participates in all stages of tumor progression and has emerged as a pro ...
»Clinical Applications of Circulating Tumor Cells in Pharmacotherapy: Challenges and Perspectives [Minireview-Molecular Pharmacology in China]
Screening for circulating tumor cells (CTCs) has been identified as one approach to ultrasensitive ...
»The Emerging Role of Cables1 in Cancer and Other Diseases [Minireview-Molecular Pharmacology in China]
Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase ...
»Advances in Hypoxia-Mediated Mechanisms in Hepatocellular Carcinoma [Minireview-Molecular Pharmacology in China]
Hepatocellular carcinoma (HCC) is the fifth most common and the third most deadly malignant tumor w ...
»Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNF{alpha} in Vascular Endothelial Cells through a PXR-Dependent Mechanism [Molecular Pharmacology in China]
Excessive activation of the NLRP3 inflammasome is implicated in cardiovascular diseases. Statins ex ...


Date published: not known
Details

»Limb-Enhancer Genie: An accessible resource of accurate enhancer predictions in the developing limb
»Polymodal allosteric regulation of Type 1 Serine/Threonine Kinase Receptors via a conserved electrostatic lock
»Host population structure impedes reversion to drug sensitivity after discontinuation of treatment
»Spatial dynamics of synthetic microbial mutualists and their parasites
»Neuron’s eye view: Inferring features of complex stimuli from neural responses
»Multidomain analyses of a longitudinal human microbiome intestinal cleanout perturbation experiment
»Efficient and accurate causal inference with hidden confounders from genome-transcriptome variation data
»Extracting replicable associations across multiple studies: Empirical Bayes algorithms for controlling the false discovery rate
»Ten simple rules to initiate and run a postdoctoral association
»Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach
»An optimal strategy for epilepsy surgery: Disruption of the rich-club?
»The application of project-based learning in bioinformatics training


Date published: not known
Details


THE FOUNDER and CEO

Parham Jabbarzadeh Kaboli, PhD

Research scientist
in molecular medicine


Expert in:

Cell and molecular Biology
Modelling and drug discovery
Cancer signaling pathways

H-index= 3 (Google Scholar)
i10-index= 3
Overall ISI impact factor= 18.15
Overall citation= 110 (Google Scholar)

Memberships:

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

European Association for Cancer Research (EACR)

American Association for Advancement of Science (AAAS)



CONTACT INFORMATION


Affiliation:
Department of Biomedical Science,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang 43400,
Selangor, Malaysia

E-Mail: parham@gromacs.net
Telegram: telegram.me/parhamacademy
Featured Publication





View the full list.
Archives

Welcome

Username:

Password:



[ ]







This site is powered by Parham Academy.
This site is powered by Parham Academy.
Render time: 0.2907 sec, 0.2156 of that for queries.