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ISI Impact factor= 5.49 (Q1)



Each weekend, you are linked to the best article that , during each week, I have read and found it great in the field of Cancer and Pharmacology. I try to encourage the fellow researchers and post-graduate students to read so much as they can about new therapeutics.
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Weekend Recipe for January 2016 - the first week

Antibody Drug Conjugates for Cancer Therapy

Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.

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Our article: Therapeutic miRNAs


 Pharmacological Research




Headlines





Date published: not known
Details

»Megafaunal loss
»A strongly oxidizing Paleoproterozoic era
»Transient instruction changes migration
»Inherited variation contributes to autism
»An innovative approach for a rare disease
»Taking an active interest in HIV latency
»Reserving the right to stretch
»Earlier detection of ovarian cancer
»Recurring coherence
»Trigenic interactions in yeast link bioprocesses


Date published: not known
Details

»Correction to "Investigation into the Mechanism of Homo- and Heterodimerization of Angiotensin-Converting Enzyme" [ERRATUM]
»Ethanol Reversal of Oxycodone Tolerance in Dorsal Root Ganglia Neurons [Articles]
Oxycodone is a semisynthetic opioid compound that is widely prescribed, used, and abused today, and ...
»Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin [Articles]
Glutathione-liganded binuclear dinitrosyl iron complex (glut-BDNIC) has been proposed to be a donor ...
»Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs [Articles]
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the ...
»Properties of Triheteromeric N-Methyl-D-Aspartate Receptors Containing Two Distinct GluN1 Isoforms [Articles]
N-Methyl-d-aspartate (NMDA)–type glutamate receptors mediate excitatory synaptic transmission ...
»High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors [Accelerated Communication]
GABAA receptors activated by the transmitter GABA are potentiated by several allosterically acting ...
»Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5 [Articles]
Adhesion G protein-coupled receptors (aGPCRs) have emerged as potential therapeutic targets in mult ...
»CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins [Articles]
The clearance of retinoic acid (RA) and its metabolites is believed to be regulated by the CYP26 en ...
»"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands [Articles]
Numerous positive and negative allosteric modulators (PAMs and NAMs) of class C G protein-coupled r ...
»The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase II{alpha} (TOP2{alpha}/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2{alpha}/170 Isoform [Articles]
DNA topoisomerase IIα (170 kDa, TOP2α/170) is essential in proliferating cells by resol ...


Date published: not known
Details

»Exploiting glycan topography for computational design of Env glycoprotein antigenicity
»Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse
»EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos
»Compositional clustering in task structure learning
»Decision making improves sperm chemotaxis in the presence of noise
»Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer
»Bayesian reconstruction of transmission within outbreaks using genomic variants
»Biogeography and environmental conditions shape bacteriophage-bacteria networks across the human microbiome
»Propagating annotations of molecular networks using in silico fragmentation
»A computational model of shared fine-scale structure in the human connectome
»On the role of extrinsic noise in microRNA-mediated bimodal gene expression
»A modelling approach for exploring muscle dynamics during cyclic contractions


Date published: not known
Details


THE FOUNDER and CEO

Parham Jabbarzadeh Kaboli, PhD

Research scientist
in molecular medicine


Expert in:

Cell and molecular Biology
Modelling and drug discovery
Cancer signaling pathways

H-index= 3 (Google Scholar)
i10-index= 3
Overall ISI impact factor= 18.15
Overall citation= 110 (Google Scholar)

Memberships:

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

European Association for Cancer Research (EACR)

American Association for Advancement of Science (AAAS)



CONTACT INFORMATION


Affiliation:
Department of Biomedical Science,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang 43400,
Selangor, Malaysia

E-Mail: parham@gromacs.net
Telegram: telegram.me/parhamacademy
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