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Each weekend, you are linked to the best article that , during each week, I have read and found it great in the field of Cancer and Pharmacology. I try to encourage the fellow researchers and post-graduate students to read so much as they can about new therapeutics.
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Weekend Recipe for January 2016 - the first week

Antibody Drug Conjugates for Cancer Therapy

Antibody drug conjugates (ADCs) constitute a family of cancer therapeutics designed to preferentially direct a cytotoxic drug to cells expressing a cell-surface antigen recognized by an antibody. The antibody and drug are linked through chemistries that enable release of the cytotoxic drug or drug adduct upon internalization and digestion of the ADC by the cell. Over 40 distinct ADCs, targeting an array of antigens and utilizing a variety of drugs and linkers, are undergoing clinical evaluation. This review primarily covers ADCs that have advanced to clinical investigation with a particular emphasis on how the individual targets, linker chemistries, and appended drugs influence their behavior.

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Our article: Therapeutic miRNAs


 Pharmacological Research




Headlines





Date published: not known
Details

»The flight of the narwhal
»Gaining a foothold on kidney disease?
»Conditions in a black hole outburst
»Watching electrons lose steam in graphene
»FAK directs tumor immune evasion
»Understanding splicing from the 3' end
»A sweet source to make acrylonitrile
»One cause of accidental deaths
»Taking a direct route to the brain
»The peopling of Asia


Date published: not known
Details

»Relationship between DNA Methylation in the 5' CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver [Articles]
Multidrug and toxin extrusion protein 1 (MATE1), which is encoded by solute carrier 47A1 (SLC47A1), ...
»Desensitization and Tolerance of Mu Opioid Receptors on Pontine Kölliker-Fuse Neurons [Articles]
Acute desensitization of mu opioid receptors is thought to be an initial step in the development of ...
»The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5 [Articles]
The contributions of cytochrome P450 3A5 to the metabolic clearance of marketed drugs is unclear, b ...
»Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family [Articles]
Since their discovery more than 20 years ago, regulators of G protein–signaling (RGS) protein ...


Date published: not known
Details

»Correction: Identifying influential neighbors in animal flocking
»Stabilizing patterns in time: Neural network approach
»Non-linear auto-regressive models for cross-frequency coupling in neural time series
»Thalamocortical control of propofol phase-amplitude coupling
»Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP
»A cyber-linked undergraduate research experience in computational biomolecular structure prediction and design
»Ten simple rules for international short-term research stays
»Automated classification of dolphin echolocation click types from the Gulf of Mexico
»Correction: Signatures of criticality arise from random subsampling in simple population models
»pSSAlib: The partial-propensity stochastic chemical network simulator
»Efficient encoding of motion is mediated by gap junctions in the fly visual system
»A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence


Date published: not known
Details


THE FOUNDER and CEO

Parham Jabbarzadeh Kaboli, PhD

Research scientist
in molecular medicine


Expert in:

Cell and molecular Biology
Modelling and drug discovery
Cancer signaling pathways

H-index= 3 (Google Scholar)
i10-index= 3
Overall ISI impact factor= 18.15
Overall citation= 110 (Google Scholar)

Memberships:

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

American Association for Cancer Research (AACR)

European Association for Cancer Research (EACR)

American Association for Advancement of Science (AAAS)



CONTACT INFORMATION


Affiliation:
Department of Biomedical Science,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia,
UPM Serdang 43400,
Selangor, Malaysia

E-Mail: parham@gromacs.net
Telegram: telegram.me/parhamacademy
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